Bupropion and naltrexone is a tablet medication that you 1-2 times a day and we don’t fully know how it works in weight. After a year of use on average it helps people lose about 4-5% of their body weight, which means 4-5kg if you are 100kg. However the trials show that 50% of people after a year had stopped the medication and a good percentage of these was due to side effects including nausea, headaches and constipation increases in blood pressure and heart rate and it should be used in caution in people under the age of 25 due to potential increase in suicidal thinking.
The other important point is the cost, which in Australia is about $200/month, which is considerable and you have to ask yourself – for 4-5 kg a year – what else could you spend that money on?
Contraindications include pregnancy, uncontrolled hypertension, seizure disorder, eating disorder, use of other bupropion-containing products, chronic opioid use, and use within 14 days of taking monoamine oxidase inhibitor medications.